Notice of Changes:

1. Updates on status of clinical activities

2. Potential market size of each pipeline’s indications

3. Addition of new preclinical data at AACR 2022 and BIO USA 2022. (PMC-309)

4. Future milestones of the Company’s R&D activities

Please check the attached file for details.

We would like to thank our shareholders, investors, and partners for their continued support.