Ophthalmology / Solid tumors
Mechanism of action / Target
PMC-403 is a monoclonal antibody that targets the human TIE2 that regulate the angiogenesis and vessel maturation in endothelial cells. It binds to TIE2 expressing endothelial cells and normalize VEGF-induced pathological leaky blood vessels in eyes and TME (tumor microenvironment).
PMC-403 was tested in various vessel-related diseases, such as AMD (Age-related Macular Degeneration), DR (Diabetic Retinopathy), and even solid tumors. In these models, significant vessel normalizing effects were found which suggest versatile use in a wide range of indications. PharmAbcine initiated the GLP-tox study of PMC-403 in 2Q21 and expects an IND filing in 3Q22.
2F, Research Building 2, 70,
Yuseong-daero 1689 beon-gil,
Yuseong-gu, Daejeon, 34047, Republic of Korea
R&D Center +82-42-861-2017
Investor Relations +70-4294-6097
COPYRIGHT BY PharmAbcine Inc.
ALL RIGHTS RESERVE