Indications: Solid tumors
PMC-402 is a monoclonal antibody that targets the human Tie2 that regulated activation, proliferation, and repolarization of Tie2 expressing macrophages, resulting in T cell activation.
Mechanism of action / Target
PMC-402 binds to TIE2 expressing macrophages that activate T cells in the tumor microenvironment (TME).
An increase in T cell activity along with a shift in polarization from M2 to M1 macrophages have been identified in the in vitro study. The production of samples needed for the GLP-Toxicity study is underway for the IND filing.