Mechanism of action / Target
PMC-309 is an engineered monoclonal antibody that targets the negative immune checkpoint human VISTA (V-domain Ig suppressor of T cell activation). It indirectly promotes T cells' immune responses by inhibiting VISTA-expressing immunosuppressive cells, such as MDSCs (Myeloid-Derived Suppressor Cells) and M1 macrophages, and Tregs that suppress T cell activation and proliferation.
The molecule's mechanism and preclinical efficacies have been confirmed in both in vitro and in vivo models. PharmAbcine initiated the GLP-tox study of PMC-309 in 2Q21 and expects an IND filing in 2Q22.
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